Computational modelling of homo- and heterosynaptic LTD: insights from STDP, metaplasticity and spontaneous activity
نویسنده
چکیده
Using the nearest-neighbour STDP rule with metaplasticity we show that to evoke homosynaptic LTD or depotentiation in the spiking model of granule cell is not easy. This is in accordance with number of experimental studies. On the other hand, heterosynaptic LTD which accompanies homosynaptic LTP is induced readily both in the model as well as in experiments. We offer possible explanation of this discrepancy based on STDP, metaplasticity and spontaneous activity. We suggest conditions under which it would be possible to induce homosynaptic LTD and depotentiation if our assumptions were correct.
منابع مشابه
Computational Modeling of Long-term Depression of Synaptic Weights: Insights from Stdp, Metaplasticity and Spontaneous Activity
Using the STDP rule with metaplasticity, we show that to evoke longterm depression (LTD) or depotentiation of synaptic weights in the spiking model of granule cell is not easy. This is in accordance with a number of experimental studies. On the other hand, heterosynaptic LTD which accompanies homosynaptic long-term potentiation (LTP) is induced readily both in the model as well as in experiment...
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متن کاملCorrection: A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo
There is an error within the main text (Methods; 2nd paragraph) of this manuscript (p. 20 in the PDF). The sentences read as follows: “. . .tau is the integration period. . .” and “We used the value of tau = 60s for all the simulations. . .” They should read: “. . .tau is the integration time constant. . .” and “We used the value of tau = 12s for all the simulations. . .” The following sentence...
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